Structural commonalities among integral membrane enzymes

Structural commonalities among integral membrane enzymes.

The X-ray crystal structures of five distinct enzymes (prostaglandin H(2) synthase, squalene cyclase, fatty acid amide hydrolase, microsomal cytochrome P450, and estrone sulfatase) challenge contemporary descriptions of integral membrane proteins. This structurally divergent group represents an important component of the integral membrane proteome that lies at the bilayer's aqueous interface. W...

Structural and behavioural commonalities of process variants

A common business process might exist in multiple variations in an enterprise, due to different legal requirements in different countries, deviations in the supporting IT infrastructure, or differences in the organisational structure. In order to explore and control such variability, we argue that the notion of a core process, the invariant nucleus of all process variants, might be applied. In ...

Lipid cubic phase as a membrane mimetic for integral membrane protein enzymes.

The lipidic cubic mesophase has been used to crystallize important membrane proteins for high-resolution structure determination. To date, however, no integral membrane enzymes have yielded to this method, the in meso. For a crystal structure to be meaningful the target protein must be functional. Using the in meso method with a membrane enzyme requires that the protein is active in the mesopha...

Structural evidence for dimerization-regulated activation of an integral membrane

Clustering and commonalities among autoimmune diseases.

The concept that autoimmune diseases are characterized by shared (common) threads is well illustrated by their propensity to co-associate in a patient or direct relatives, as coexistences or overlaps. Recognized are two major autoimmune clusters, "thyrogastric" (mostly organ-specific) and "lupus-associated" (mostly multisystem). Additionally, some autoimmune diseases distribute within either cl...